{"id":181950,"date":"2024-11-09T19:51:21","date_gmt":"2024-11-09T11:51:21","guid":{"rendered":"https:\/\/server.hk\/cnblog\/181950\/"},"modified":"2024-11-09T19:51:22","modified_gmt":"2024-11-09T11:51:22","slug":"%e6%b7%b1%e5%85%a5%e6%8e%a2%e7%b4%a2microarray%e6%95%b8%e6%93%9a%e5%ba%ab%ef%bc%8c%e6%8f%ad%e7%a4%ba%e5%9f%ba%e5%9b%a0%e4%ba%a4%e4%ba%92%e5%8f%8a%e8%a1%a8%e9%81%94%e6%a8%a1%e5%bc%8f%ef%bc%88microarray","status":"publish","type":"post","link":"https:\/\/server.hk\/cnblog\/181950\/","title":{"rendered":"\u6df1\u5165\u63a2\u7d22Microarray\u6578\u64da\u5eab\uff0c\u63ed\u793a\u57fa\u56e0\u4ea4\u4e92\u53ca\u8868\u9054\u6a21\u5f0f\uff08microarray\u6578\u64da\u5eab\uff09"},"content":{"rendered":"<h1 id=\"%e6%b7%b1%e5%85%a5%e6%8e%a2%e7%b4%a2microarray%e6%95%b8%e6%93%9a%e5%ba%ab%ef%bc%8c%e6%8f%ad%e7%a4%ba%e5%9f%ba%e5%9b%a0%e4%ba%a4%e4%ba%92%e5%8f%8a%e8%a1%a8%e9%81%94%e6%a8%a1%e5%bc%8f-ApJsuIApUO\">\u6df1\u5165\u63a2\u7d22Microarray\u6578\u64da\u5eab\uff0c\u63ed\u793a\u57fa\u56e0\u4ea4\u4e92\u53ca\u8868\u9054\u6a21\u5f0f<\/h1>\n<p>Microarray\u6280\u8853\u662f\u4e00\u7a2e\u5f37\u5927\u7684\u5de5\u5177\uff0c\u5ee3\u6cdb\u61c9\u7528\u65bc\u57fa\u56e0\u8868\u9054\u5206\u6790\u3001\u57fa\u56e0\u7d44\u5b78\u53ca\u751f\u7269\u91ab\u5b78\u7814\u7a76\u3002\u900f\u904e\u9019\u9805\u6280\u8853\uff0c\u7814\u7a76\u4eba\u54e1\u80fd\u5920\u540c\u6642\u6aa2\u6e2c\u6210\u5343\u4e0a\u842c\u7684\u57fa\u56e0\u8868\u9054\u6c34\u5e73\uff0c\u5f9e\u800c\u63ed\u793a\u57fa\u56e0\u4e4b\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\u53ca\u5176\u5728\u4e0d\u540c\u751f\u7269\u904e\u7a0b\u4e2d\u7684\u8868\u73fe\u6a21\u5f0f\u3002\u672c\u6587\u5c07\u6df1\u5165\u63a2\u8a0eMicroarray\u6578\u64da\u5eab\u7684\u529f\u80fd\u53ca\u5176\u5728\u57fa\u56e0\u7814\u7a76\u4e2d\u7684\u91cd\u8981\u6027\u3002<\/p>\n<h2 id=\"microarray%e6%8a%80%e8%a1%93%e6%a6%82%e8%bf%b0-ApJsuIApUO\">Microarray\u6280\u8853\u6982\u8ff0<\/h2>\n<p>Microarray\u6280\u8853\u5229\u7528\u4e00\u500b\u5c0f\u578b\u7684\u56fa\u9ad4\u57fa\u8cea\uff08\u5982\u73bb\u7483\u7247\u6216\u7845\u7247\uff09\uff0c\u5728\u5176\u8868\u9762\u4e0a\u56fa\u5b9a\u5927\u91cf\u7684\u5be1\u6838\u82f7\u9178\u63a2\u91dd\u3002\u9019\u4e9b\u63a2\u91dd\u80fd\u5920\u7279\u7570\u6027\u5730\u8207\u6a23\u672c\u4e2d\u7684mRNA\u7d50\u5408\uff0c\u4e26\u901a\u904e\u6a19\u8a18\u7684\u65b9\u5f0f\u9032\u884c\u6aa2\u6e2c\u3002\u7576\u6a23\u672c\u4e2d\u7684mRNA\u8207\u63a2\u91dd\u7d50\u5408\u5f8c\uff0c\u6703\u7522\u751f\u53ef\u88ab\u6383\u63cf\u5100\u6aa2\u6e2c\u7684\u4fe1\u865f\uff0c\u5f9e\u800c\u91cf\u5316\u57fa\u56e0\u7684\u8868\u9054\u6c34\u5e73\u3002<\/p>\n<h2 id=\"microarray%e6%95%b8%e6%93%9a%e5%ba%ab%e7%9a%84%e5%8a%9f%e8%83%bd-ApJsuIApUO\">Microarray\u6578\u64da\u5eab\u7684\u529f\u80fd<\/h2>\n<p>Microarray\u6578\u64da\u5eab\u662f\u5b58\u5132\u548c\u7ba1\u7406Microarray\u5be6\u9a57\u6578\u64da\u7684\u5c08\u9580\u5e73\u53f0\u3002\u9019\u4e9b\u6578\u64da\u5eab\u4e0d\u50c5\u63d0\u4f9b\u4e86\u57fa\u56e0\u8868\u9054\u6578\u64da\uff0c\u9084\u5305\u542b\u4e86\u8c50\u5bcc\u7684\u5143\u6578\u64da\uff0c\u5982\u6a23\u672c\u4f86\u6e90\u3001\u5be6\u9a57\u689d\u4ef6\u53ca\u5206\u6790\u7d50\u679c\u7b49\u3002\u4ee5\u4e0b\u662fMicroarray\u6578\u64da\u5eab\u7684\u4e00\u4e9b\u4e3b\u8981\u529f\u80fd\uff1a<\/p>\n<ul>\n<li><strong>\u6578\u64da\u5b58\u5132\u8207\u6aa2\u7d22\uff1a<\/strong>\u7814\u7a76\u4eba\u54e1\u53ef\u4ee5\u5c07\u5be6\u9a57\u6578\u64da\u4e0a\u50b3\u81f3\u6578\u64da\u5eab\uff0c\u4e26\u901a\u904e\u95dc\u9375\u5b57\u6216\u57fa\u56e0\u540d\u7a31\u9032\u884c\u6aa2\u7d22\u3002<\/li>\n<li><strong>\u6578\u64da\u5171\u4eab\uff1a<\/strong>\u4fc3\u9032\u4e0d\u540c\u7814\u7a76\u5718\u968a\u4e4b\u9593\u7684\u6578\u64da\u5171\u4eab\uff0c\u63a8\u52d5\u79d1\u5b78\u7814\u7a76\u7684\u9032\u5c55\u3002<\/li>\n<li><strong>\u6578\u64da\u5206\u6790\u5de5\u5177\uff1a<\/strong>\u8a31\u591a\u6578\u64da\u5eab\u63d0\u4f9b\u5167\u5efa\u7684\u6578\u64da\u5206\u6790\u5de5\u5177\uff0c\u5e6b\u52a9\u7528\u6236\u9032\u884c\u57fa\u56e0\u8868\u9054\u5206\u6790\u3001\u5dee\u7570\u5206\u6790\u53ca\u529f\u80fd\u8a3b\u91cb\u3002<\/li>\n<\/ul>\n<h2 id=\"microarray%e6%95%b8%e6%93%9a%e5%ba%ab%e7%9a%84%e4%be%8b%e5%ad%90-ApJsuIApUO\">Microarray\u6578\u64da\u5eab\u7684\u4f8b\u5b50<\/h2>\n<p>\u76ee\u524d\u6709\u591a\u500b\u77e5\u540d\u7684Microarray\u6578\u64da\u5eab\u53ef\u4f9b\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\uff0c\u5176\u4e2d\u5305\u62ec\uff1a<\/p>\n<ul>\n<li><strong>Gene Expression Omnibus (GEO)\uff1a<\/strong>\u7531\u7f8e\u570b\u570b\u7acb\u751f\u7269\u6280\u8853\u4fe1\u606f\u4e2d\u5fc3\uff08NCBI\uff09\u7dad\u8b77\uff0cGEO\u662f\u6700\u5ee3\u6cdb\u4f7f\u7528\u7684Microarray\u6578\u64da\u5eab\u4e4b\u4e00\uff0c\u63d0\u4f9b\u4e86\u5927\u91cf\u7684\u57fa\u56e0\u8868\u9054\u6578\u64da\u548c\u76f8\u95dc\u7684\u5143\u6578\u64da\u3002<\/li>\n<li><strong>ArrayExpress\uff1a<\/strong>\u7531\u6b50\u6d32\u751f\u7269\u4fe1\u606f\u5b78\u7814\u7a76\u6240\uff08EBI\uff09\u63d0\u4f9b\uff0cArrayExpress\u540c\u6a23\u662f\u4e00\u500b\u91cd\u8981\u7684\u6578\u64da\u5eab\uff0c\u5c08\u6ce8\u65bc\u57fa\u56e0\u8868\u9054\u6578\u64da\u7684\u5b58\u5132\u548c\u5206\u6790\u3002<\/li>\n<li><strong>Oncomine\uff1a<\/strong>\u5c08\u6ce8\u65bc\u764c\u75c7\u7814\u7a76\u7684Microarray\u6578\u64da\u5eab\uff0c\u63d0\u4f9b\u4e86\u5927\u91cf\u8207\u764c\u75c7\u76f8\u95dc\u7684\u57fa\u56e0\u8868\u9054\u6578\u64da\uff0c\u5e6b\u52a9\u7814\u7a76\u4eba\u54e1\u7406\u89e3\u764c\u75c7\u7684\u5206\u5b50\u6a5f\u5236\u3002<\/li>\n<\/ul>\n<h2 id=\"%e5%9f%ba%e5%9b%a0%e4%ba%a4%e4%ba%92%e5%8f%8a%e8%a1%a8%e9%81%94%e6%a8%a1%e5%bc%8f%e7%9a%84%e6%8f%ad%e7%a4%ba-ApJsuIApUO\">\u57fa\u56e0\u4ea4\u4e92\u53ca\u8868\u9054\u6a21\u5f0f\u7684\u63ed\u793a<\/h2>\n<p>\u901a\u904e\u5206\u6790Microarray\u6578\u64da\uff0c\u7814\u7a76\u4eba\u54e1\u53ef\u4ee5\u63ed\u793a\u57fa\u56e0\u4e4b\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\u53ca\u5176\u5728\u4e0d\u540c\u751f\u7269\u904e\u7a0b\u4e2d\u7684\u8868\u9054\u6a21\u5f0f\u3002\u4f8b\u5982\uff0c\u67d0\u4e9b\u57fa\u56e0\u53ef\u80fd\u5728\u7279\u5b9a\u7684\u751f\u7406\u689d\u4ef6\u4e0b\u8868\u9054\u4e0a\u8abf\uff0c\u800c\u5728\u5176\u4ed6\u689d\u4ef6\u4e0b\u5247\u8868\u9054\u4e0b\u8abf\u3002\u9019\u4e9b\u4fe1\u606f\u5c0d\u65bc\u7406\u89e3\u75be\u75c5\u6a5f\u5236\u3001\u85e5\u7269\u4f5c\u7528\u53ca\u751f\u7269\u9ad4\u7684\u9069\u61c9\u6027\u53cd\u61c9\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5229\u7528\u751f\u7269\u4fe1\u606f\u5b78\u5de5\u5177\uff0c\u7814\u7a76\u4eba\u54e1\u53ef\u4ee5\u9032\u4e00\u6b65\u5206\u6790\u57fa\u56e0\u7db2\u7d61\uff0c\u63a2\u7d22\u57fa\u56e0\u4e4b\u9593\u7684\u8abf\u63a7\u95dc\u4fc2\u3002\u4f8b\u5982\uff0c\u4f7f\u7528<code>R<\/code>\u8a9e\u8a00\u4e2d\u7684<code>limma<\/code>\u5305\u9032\u884c\u5dee\u7570\u8868\u9054\u5206\u6790\uff0c\u53ef\u4ee5\u5e6b\u52a9\u8b58\u5225\u5728\u7279\u5b9a\u689d\u4ef6\u4e0b\u986f\u8457\u4e0a\u8abf\u6216\u4e0b\u8abf\u7684\u57fa\u56e0\u3002<\/p>\n<pre><code>\n# \u5b89\u88ddlimma\u5305\ninstall.packages(\"limma\")\n\n# \u8f09\u5165limma\u5305\nlibrary(limma)\n\n# \u5047\u8a2dexprs\u662f\u57fa\u56e0\u8868\u9054\u6578\u64da\uff0cdesign\u662f\u5be6\u9a57\u8a2d\u8a08\u77e9\u9663\nfit &lt;- lmFit(exprs, design)\nfit &lt;- eBayes(fit)\nresults &lt;- topTable(fit, adjust=&quot;fdr&quot;, sort.by=&quot;B&quot;, number=Inf)\n<\/code><\/pre>\n<h2 id=\"%e7%b5%90%e8%ab%96-ApJsuIApUO\">\u7d50\u8ad6<\/h2>\n<p>Microarray\u6578\u64da\u5eab\u5728\u57fa\u56e0\u7814\u7a76\u4e2d\u626e\u6f14\u8457\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\uff0c\u901a\u904e\u63d0\u4f9b\u8c50\u5bcc\u7684\u6578\u64da\u548c\u5206\u6790\u5de5\u5177\uff0c\u5e6b\u52a9\u7814\u7a76\u4eba\u54e1\u6df1\u5165\u7406\u89e3\u57fa\u56e0\u4ea4\u4e92\u53ca\u8868\u9054\u6a21\u5f0f\u3002\u96a8\u8457\u6280\u8853\u7684\u9032\u6b65\u548c\u6578\u64da\u91cf\u7684\u589e\u52a0\uff0c\u9019\u4e9b\u6578\u64da\u5eab\u5c07\u7e7c\u7e8c\u63a8\u52d5\u751f\u7269\u91ab\u5b78\u7814\u7a76\u7684\u767c\u5c55\uff0c\u70ba\u75be\u75c5\u7684\u8a3a\u65b7\u548c\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u6709\u95dc\u65bc<code>VPS<\/code>\u3001<code>\u9999\u6e2fVPS<\/code>\u53ca\u5176\u4ed6\u76f8\u95dc\u670d\u52d9\u7684\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u6211\u5011\u7684\u7db2\u7ad9 <a href=\"https:\/\/server.hk\">Server.HK<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6df1\u5165\u63a2\u7d22Microarray\u6578\u64da\u5eab\uff0c\u63ed\u793a\u57fa\u56e0\u4ea4\u4e92\u53ca\u8868\u9054\u6a21\u5f0f\uff0c\u52a9\u529b\u751f\u7269\u7814\u7a76\u8207\u75be\u75c5\u8a3a\u65b7\u7684\u7a81\u7834\u6027\u767c\u73fe\u3002<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101],"tags":[],"class_list":["post-181950","post","type-post","status-publish","format-standard","hentry","category-database"],"_links":{"self":[{"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/posts\/181950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/comments?post=181950"}],"version-history":[{"count":1,"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/posts\/181950\/revisions"}],"predecessor-version":[{"id":181951,"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/posts\/181950\/revisions\/181951"}],"wp:attachment":[{"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/media?parent=181950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/categories?post=181950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/server.hk\/cnblog\/wp-json\/wp\/v2\/tags?post=181950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}